XWH - 06 - 1 - 0724 TITLE : CD 4 + Th 1 HER 2 - Specific T cells as a Novel Treatment for HER 2 - Overexpressing Breast Cancer

Aloe-emodin inhibits HER-2 expression through the downregulation of Y-box binding protein-1 in HER-2-overexpressing human breast cancer cells

Human epidermal growth factor receptor-2 (HER-2)-positive breast cancer tends to be aggressive, highly metastatic, and drug resistant and spreads rapidly. Studies have indicated that emodin inhibits HER-2 expression. This study compared the HER-2-inhibitory effects of two compounds extracted from rhubarb roots: aloe-emodin (AE) and rhein. Our results indicated that AE exerted the most potent in...

XWH - 10 - 1 - 0051 TITLE : Hsf 1 in Her 2 - positive Breast Cancer

XWH - 10 - 1 - 1005 TITLE : Role of PTP 1 B in HER 2 Signaling in Breast Cancer

Novel paradigm for immunotherapy of breast cancer by engaging prophylactic immunity against hepatitis B

BACKGROUND Immunotherapy of patients suffering from the human epidermal growth factor receptor 2 overexpressing (HER-2(+)) breast cancers with the anti-HER-2 antibodies results in increase of the patients' overall survival. However, no prophylactic vaccine is available against HER-2(+) breast cancers. Although, prophylactic vaccine for human hepatitis B virus (HBV) is very effective. SPECIFIC...

Award Number : W 81 XWH - 08 - 1 - 0640 TITLE : Expression of Endogenous Suppressors of HER 2 Overexpression in Breast Cancer PRINCIPAL INVESTIGATOR : Kermit L . Carraway